Post Hoc Analyses Of Surrogate Markers Of Non Alcoholic Fatty Liver Disease (NAFLD) And Liver Fibrosis In Patients With Type 2 Diabetes In A Digitally Supported Continuous Care Intervention An Open Label, Non Randomised Controlled Study

This study examined whether a comprehensive digital health intervention could improve liver health in people with type 2 diabetes. Non-alcoholic fatty liver disease (NAFLD) - where fat builds up in the liver without alcohol being the cause - affects up to 95% of people with type 2 diabetes and can progress to serious liver damage. Researchers followed 262 patients using a digitally-supported continuous care program focused on achieving nutritional ketosis (where the body burns fat for fuel instead of sugar) and compared them to 87 patients receiving usual diabetes care.

The results were striking. After one year, 79% of patients in the digital intervention group achieved significant weight loss (5% or more) compared to only 19% in the usual care group. More importantly, liver health markers improved dramatically in the intervention group. The liver fat score, which estimates the amount of fat in the liver, decreased significantly in the digital program participants while remaining unchanged in the usual care group. Similarly, markers of liver scarring (fibrosis) improved substantially - the percentage of people with low probability of advanced liver damage nearly doubled from 18% to 33%.

These findings suggest that comprehensive lifestyle interventions using digital support and nutritional approaches can meaningfully reverse liver damage in people with diabetes. Since liver disease is often a "silent" condition that progresses without obvious symptoms, these improvements in measurable markers are particularly encouraging. This research supports the growing evidence that metabolic interventions targeting root causes - rather than just managing symptoms - can help restore organ health and potentially extend healthspan in people with metabolic dysfunction.