Metabolic
Library
1,810 peer-reviewed papers, each with a plain-language summary and the source document. The evidence behind the VALIA method, kept where you can read it.
Educational information only. Not medical advice, diagnosis or treatment. For anything about your own health, speak with a clinician. To become a patient, start at our contact page.
1,810 papers
· 13 topics
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1,810 results · page 1 of 38
- Hormone Health
‘Obesity’ Is Healthy For Cetaceans Evidence From Pervasive Positive Selection In Genes Related To Triacylglycerol Metabolism
Scientists found that whales and dolphins evolved special genes that help them store large amounts of fat as a healthy adaptation for ocean life.
- Gut Health
‘The Way To A Man S Heart Is Through His Gut Microbiota’ – Dietary Pro And Prebiotics For The Management Of Cardiovascular Risk
Your gut bacteria may significantly influence your heart disease risk, and eating more fiber-rich plants and taking specific probiotics could help protect your cardiovascular health.
- Environment and Health
“Cellular Agriculture” Current Gaps Between Facts And Claims Regarding “cell Based Meat”
This research examines the gap between bold promises about lab-grown "cell-based meat" and the current reality that technical challenges still prevent these products from reaching market.
- Evolutionary Health and Aging
“The Red Lady Of El Mirón”. Lower Magdalenian Life And Death In Oldest Dryas1 Cantabrian Spain An Overview
Scientists studied the 18,700-year-old burial of a healthy woman in Spain to understand how ancient hunter-gatherers lived, ate, and survived in harsh Ice Age conditions.
- Heart Health
1 S2.0 S1550413123005053 Main
Statins may worsen blood sugar control by disrupting gut bacteria that produce helpful compounds for insulin function.
- Brain and Nerve Health
1,25 Dihydroxyvitamin D3 Reversibly Blocks The Progression Of Relapsing Encephalomyelitis, A Model Of Multiple Sclerosis
Researchers found that the active form of vitamin D can prevent and halt progression of a mouse model of multiple sclerosis, while vitamin D deficiency increases disease risk.
- Brain and Nerve Health
2 Deoxyglucose And Beta Hydroxybutyrate Metabolic Agents For Seizure Control
Researchers are studying two natural compounds - 2-deoxyglucose and beta-hydroxybutyrate - as potential "diet in a pill" alternatives to help control seizures through metabolic changes rather than traditional medications.
- Evolutionary Health and Aging
3.3 Million Years Of Stone Tool Complexity Suggests That Cumulative Culture Began During The Middle Pleistocene
Researchers found that human ancestors' stone tools remained simple for millions of years, then suddenly became complex around 600,000 years ago, marking when humans began building knowledge across generations.
- Environment and Health
90 Day Dietary Toxicity Study Of EPG
A 90-day study found that EPG, a fat substitute designed to reduce calories, lowered vitamin D levels in pigs without causing obvious health problems.
- Hormone Health
A B Hydroxybutyrate Shunt Pathway Generates Antiobesity Ketone Metabolites
Scientists discovered that the body naturally creates special ketone compounds that help reduce appetite and body weight, offering new insights into how ketosis may support weight management.
- Hormone Health
A B Hydroxybutyrate Shunt Pathway Generates Antiobesity Ketone Metabolites(1)
Researchers discovered that the body creates special compounds from ketones (produced during fasting or low-carb diets) that naturally suppress appetite and promote weight loss.
- Evolutionary Health and Aging
A Bioenergetic Approach Favors The Preservation And Protection Of Prey, Not Cooking, As The Drivers Of Early Fire
New research suggests early humans first used fire to preserve meat and protect themselves from predators, not for cooking food.
- Gut Health
A Cause Effect Relationship Between Graves Disease And The Gut Micobiome
Researchers found a two-way causal relationship between Graves' disease (an autoimmune thyroid condition) and gut bacteria, confirming that gut health directly influences thyroid function.
- Hormone Health
A Cellular And Molecular Basis For Leptin Resistance
Researchers discovered why leptin (the "fullness hormone") stops working in obesity and found that a drug called rapamycin can restore leptin's appetite-suppressing effects.
- Hormone Health
A Cellular And Molecular Basis For Leptin Resistance OCRed
Researchers discovered why the hormone leptin stops working properly in obesity and found that a drug called rapamycin can restore leptin's appetite-suppressing effects.
- Gut Health
A Common Dietary Fiber Promotes Allergy Like Immune Responses In Preclinical Studies ScienceDaily
Researchers found that inulin, a popular fiber supplement, may trigger allergy-like inflammation in the lungs and gut in laboratory studies.
- Heart Health
A Comparison Of The Mouse And Human Lipoproteome Suitability Of The Mouse Model For Studies Of Human Lipoproteins
Researchers compared cholesterol-carrying particles in mice and humans to determine if mouse studies accurately reflect human heart health research.
- Nutrition and Health
A Concise Review Of Ketogenic Dietary Interventions In The Management Of Rare Diseases
This review examines how ketogenic diets (high-fat, very low-carb eating patterns) are being used as supportive treatments for various rare genetic diseases.
- Nutrition and Health
A Critical Assessment Of Some Biomarker Approaches Linked With Dietary Intake
This research examines how scientists measure nutrients and food compounds in the body, revealing that different testing methods can give varying results.
- Heart Health
A Definition Of The Intima Of Human Arteries And Of Its Atherosclerosis Prone Regions. A Report From The Committee On Vascular Lesions Of The Council On Arteriosclerosis, American Heart Association
This American Heart Association report establishes scientific definitions to help doctors distinguish between normal artery wall changes and early atherosclerosis (plaque buildup).
- Nutrition and Health
A Diet Based On High Heat Treated Foods Promotes Ris 2010 The American Journ
A study found that eating high-heat cooked foods for just one month reduced insulin sensitivity and increased cholesterol compared to eating gently steamed foods.
- Hormone Health
A Diet Containing Animal Source Protein As Fresh, Lean Beef Is More Well Liked And Promotes Healthier Eating Behavior Compared With Plant Based Alternatives In Women With Overweight
A study found that women with overweight preferred lean beef over plant-based protein alternatives and naturally ate less sugar when including beef in their diet.
- Nutrition and Health
A Diet Rich In Coconut Oil Reduces Diurnal Postprandial Variati 2003 The Jou
This study found that a coconut oil-rich diet improved certain blood clotting factors and reduced harmful lipoprotein(a) levels compared to diets high in unsaturated fats.
- Liver and Kidney Health
A Dietary Ketone Ester Mitigates Histological Outcomes Of NAFLD And Markers Of Fibrosis In High Fat Diet Fed Mice
A ketone supplement reduced liver fat buildup and inflammation in mice eating a high-fat diet, suggesting potential benefits for fatty liver disease.
- Nutrition and Health
A Dose Response Crossover Iodine Balance Study To 2016 The American Journal
Researchers determined that infants aged 2-5 months need about 70-80 micrograms of iodine daily for proper brain development and thyroid function.
- Nutrition and Health
A Framework For Assessing Effects Of The Food System
This National Academies report presents a comprehensive framework for evaluating how our food system affects human health, environmental sustainability, and social well-being.
- Dental Health
A Healthier Smile In The Past Dental Caries And Diet In Early Neolithic Farming Communities From Central Germany
Ancient farmers from 7,000 years ago had surprisingly high rates of tooth decay despite eating whole foods, showing diet composition significantly affects dental health.
- Nutrition and Health
A Healthy Lifestyle Pattern And The Risk Of Symptoma 2020 The American Journ
Following six healthy lifestyle habits together reduced the risk of developing painful gallstones by 74% compared to having none of these habits.
- Heart Health
A High Fat Meal Enriched With Eicosapentaenoic Acid Reduces P 2008 The Journ
Adding EPA (a healthy omega-3 fat from fish) to a high-fat meal improved blood vessel flexibility in healthy men within 6 hours.
- Liver and Kidney Health
A History Of Diabetes Mellitus Or How A Disease Of The Kidneys Evolved Into A Kidney Disease
This historical review traces how diabetes was originally thought to be a kidney disease for centuries before scientists discovered it actually originates from problems with blood sugar and insulin.
- Hormone Health
A History Of Kidney Diseae And DM
This historical review explains how diabetes was originally thought to be a kidney disease for centuries before scientists discovered it's actually caused by problems with the pancreas and insulin.
- Liver and Kidney Health
A History Of Obesity, Or How What Was Good Became Ugly And Then Bad
This article traces how obesity transformed from being considered desirable throughout most of human history to being recognized as a serious health condition linked to kidney disease.
- Joint, Muscle Health and Exercise
A Ketogenic Diet Alters MTOR Activity, Systemic Metabolism And Potentially Prevents Collagen Degradation Associated With Chronic Alcohol Consumption In Mice
A ketogenic diet may protect against bone and joint damage from chronic alcohol use by altering metabolism and reducing inflammation pathways.
- Joint, Muscle Health and Exercise
A Ketogenic Diet Combined With Exercise Alters Mitochondrial Function In Human Skeletal Muscle While Improving Metabolic Health
A 12-week study found that combining a ketogenic diet with exercise improved how muscle cells produce energy while reducing insulin resistance and belly fat.
- Joint, Muscle Health and Exercise
A Ketogenic Diet Combined With Exercise Alters Mitochondrial Function In Human Skeletal Muscle While Improving Metabolic Health(1)
A 12-week study found that combining a ketogenic diet with exercise improved how muscle cells produce energy while reducing insulin resistance and belly fat.
- Brain and Nerve Health
A Ketogenic Diet Reduces Amyloid Beta 40 And 42 In A Mouse Model Of Alzheimer S Disease
A ketogenic diet (very low carbs, high fat) reduced harmful brain proteins linked to Alzheimer's disease by 25% in mice genetically prone to the condition.
- Gut Health
A Ketogenic Diet Substantially Reshapes The Human Metabolome
A three-week ketogenic diet dramatically changed participants' metabolism, reducing insulin levels and shifting the body to burn fat while increasing anti-inflammatory compounds.
- Brain and Nerve Health
A Ketogenic Diet Suppresses Seizures In Mice Through Adenosine A1 Receptors
Researchers discovered that ketogenic diets reduce seizures in mice by boosting a brain chemical called adenosine, which has a natural calming effect on brain cells.
- Evolutionary Health and Aging
A Limited Protein High Fat Diet May Explain The Low δ66Zn Conundrum In The Neandertal From Gabasa
Researchers found that Neanderthals likely ate a high-fat, moderate-protein diet similar to modern ketogenic diets, which may offer insights into human metabolic adaptation.
- Hormone Health
A Low Carbohydrate, Ketogenic Diet Versus A Low Fat Diet To Treat Obesity And Hyperlipidemia
A study of 120 overweight people found that those following a very low-carb ketogenic diet lost twice as much weight and showed better cholesterol improvements than those on a low-fat diet.
- Heart Health
A Low Fat Diet Decreases High Density Lipoprotein (HDL) Cholesterol Levels By Decreasing HDL Apolipoprotein Transport Rates
Low-fat diets reduce "good" HDL cholesterol levels by decreasing the body's production of HDL particles, not by increasing their breakdown.
- Heart Health
A Mediterranean Diet Supplemented With Dairy Foods Impr 2018 The American Jo
Adding dairy foods to a Mediterranean diet improved blood pressure and cholesterol levels in adults at risk for heart disease.
- Joint, Muscle Health and Exercise
A Mediterranean Like Dietary Pattern With Vitamin D3 10 2018 The American
A Mediterranean-style diet with vitamin D supplements helped reduce bone loss in older adults with osteoporosis over one year.
- Joint, Muscle Health and Exercise
A Mediterranean Like Dietary Pattern With Vitamin D3 10 2018 The American(1)
A Mediterranean-style diet with vitamin D supplements helped slow bone loss in older adults with osteoporosis over one year.
- Heart Health
A Mediterranean Style Eating Pattern With Lean Unprocesse 2018 The American
A Mediterranean-style diet with moderate amounts of lean, unprocessed red meat provided heart health benefits for overweight adults, challenging the idea that red meat must be avoided.
- Environment and Health
A Metabolomics Comparison Of Plant Based Meat And Grass Fed Meat Indicates Large Nutritional Differences Despite Comparable Nutrition Facts Panels
Researchers found significant nutritional differences between grass-fed beef and plant-based meat alternatives, despite their nutrition labels appearing similar.
- Heart Health
A Multicenter Randomized Controlled Trial Of A Plant Based Nutrition Program To Reduce Body Weight And Cardiovascular Risk In The Corporate Setting The GEICO Study
A study of corporate employees found that following a low-fat plant-based diet for 18 weeks led to significant weight loss and improved cholesterol and blood sugar levels.
- Evolutionary Health and Aging
A Neandertal Dietary Conundrum Insights Provided By Tooth Enamel Zn Isotopes From Gabasa, Spain
Scientists analyzed ancient Neanderthal teeth and found evidence that our extinct human relatives were dedicated meat-eaters with unusually high levels of certain chemical markers.
Disclaimer: this library, including every summary, is for general informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before changing your diet, exercise, or health regimen, or if you have questions about a medical condition.