Blood Biomarker Profiles And Exceptional Longevity Comparison Of Centenarians And Non‑centenarians In A 35‑year Follow‑up Of The Swedish AMORIS Cohort

Researchers in Sweden studied blood test results from over 1,200 people who eventually became centenarians (lived to 100) and compared them to people who died earlier. They followed participants for 35 years, looking at blood samples taken when people were between ages 64-99 to see if there were early signs that predicted exceptional longevity.

The study found that future centenarians had distinctly different blood biomarker profiles decades before reaching 100. Specifically, they had higher levels of total cholesterol and iron, along with lower levels of blood glucose, creatinine (kidney function marker), uric acid, and several liver enzymes. These differences were apparent from age 65 onward, suggesting that the biological foundations for exceptional longevity are established relatively early in what we consider "older age."

Importantly, the centenarians showed remarkably similar biomarker patterns to each other, indicating there may be common biological pathways to exceptional longevity. The researchers noted that these favorable biomarker profiles likely reflect both genetic advantages and lifestyle factors that support healthy aging.

This research suggests that routine blood tests may offer valuable insights into longevity potential and highlight specific metabolic targets for healthy aging. For clinical practice, these findings support the importance of monitoring and optimizing metabolic markers like blood sugar, cholesterol ratios, and organ function markers as part of a comprehensive longevity-focused health strategy, rather than just treating them as isolated disease risk factors.