Statin Use Is Associated With A Decline In Muscle Function And Mass Over Time, Irrespective Of Statin Pharmacogenomic Score

Researchers analyzed data from nearly 300,000 people in the UK Biobank to investigate whether statin medications—commonly prescribed to lower cholesterol and prevent heart disease—affect muscle health over time. They measured participants' grip strength and muscle mass, then followed up with over 35,000 people for an average of 10 years to track changes.

The study revealed that statin users had lower muscle strength and mass at the start, and those who continued taking statins experienced faster muscle decline over the years compared to people who never used these medications. Specifically, continuous statin users showed 25% greater decline in grip strength and 73% greater decline in muscle mass compared to non-users. The researchers also tested whether genetic factors that influence how people respond to statins might explain these differences, but found that genetics didn't significantly change the pattern of muscle decline.

These findings are particularly relevant for metabolic health and longevity because maintaining muscle mass and strength becomes increasingly important as we age. Muscle loss (sarcopenia) is associated with frailty, falls, reduced quality of life, and increased mortality risk. While statins provide important cardiovascular benefits, this research suggests the need for a balanced approach.

For clinical practice, this highlights the importance of monitoring muscle health in patients taking statins and potentially implementing strategies like resistance training and adequate protein intake to counteract muscle loss. Patients shouldn't stop statins without consulting their doctor, but should discuss comprehensive approaches to maintain both heart and muscle health.