Metabolic
Library
1,810 peer-reviewed papers, each with a plain-language summary and the source document. The evidence behind the VALIA method, kept where you can read it.
Educational information only. Not medical advice, diagnosis or treatment. For anything about your own health, speak with a clinician. To become a patient, start at our contact page.
1,810 papers
· 13 topics
Heart Health results
360 results in Heart Health · page 7 of 8
- Heart Health
Relationship Of Carotid Intima Media Thickness And Duration Of Vegetarian Diet In Chinese Male Vegetarians
This study found that Chinese men following vegetarian diets had healthier arteries and better heart disease risk factors compared to meat-eaters.
- Heart Health
Relationship Of Glucose And Insulin Levels To The Risk Of Myocardial Infarction A Case Control Study
Even mildly elevated blood sugar levels in people without diabetes significantly increase the risk of heart attacks.
- Heart Health
Relationships Among Insulin Resistance, Obesity, Diagnosis Of The Metabolic Syndrome And Cardio Metabolic Risk
This study found that the standard metabolic syndrome diagnosis misses many insulin-resistant people who still have increased heart disease risk, and waist measurement isn't better than BMI for predicting insulin resistance.
- Heart Health
Rous Whipple Award Lecture. Atherosclerosis A Defense Mechanism Gone Awry
Atherosclerosis (artery-clogging plaque) develops when the body's natural defense and healing responses in blood vessel walls become excessive and harmful over time.
- Heart Health
Ruminant And Industrial Sources Of Trans Fat And Cardiovascular And Diabetic Diseases
This research explores how different sources of trans fats - from processed foods versus natural dairy and meat products - may have different effects on heart disease and diabetes risk.
- Heart Health
Salt Responsive Metabolite, β Hydroxybutyrate, Att
Researchers found that high-salt diets lower a beneficial ketone called beta-hydroxybutyrate, and supplementing with its precursor can help reduce blood pressure.
- Heart Health
Salt Responsive Metabolite, β Hydroxybutyrate, Attenuates Hypertension
Researchers found that high salt intake lowers a beneficial compound called beta-hydroxybutyrate, and supplementing it through diet may help reduce blood pressure.
- Heart Health
Saturated And Unsaturated Dietary Fats And Cardiometabolic Risk In The Framingham Offspring Study
A large 18-year study found that eating saturated fats did not increase heart disease or diabetes risk, and may actually support better metabolic health.
- Heart Health
Saturated Fat And Health
New research challenges long-standing advice to limit saturated fat, finding that foods like whole dairy and unprocessed meat don't increase heart disease risk as previously thought.
- Heart Health
Screening For Lipid Disorders In Adults Recommendations And Rationale
The U.S. Preventive Services Task Force strongly recommends cholesterol screening for men starting at age 35 and women at age 45 to prevent heart disease.
- Heart Health
Secular Trends In Risk Profiles Among Adults With CV Disease In The USA
A 20-year study found that Americans with heart disease are getting worse at controlling blood sugar, weight, and blood pressure, though cholesterol management has improved.
- Heart Health
Secular Trends Risk Profiles CVD
A 20-year study found that adults with heart disease got worse at controlling weight, blood sugar, and blood pressure, despite medical advances.
- Heart Health
Settings Order Article Reprints Open AccessArticle Postprandial Lipid Metabolism In Normolipidemic Subjects And Patients With Mild To Moderate Hypertriglyceridemia
Researchers found that meals with medium-chain fats (like coconut oil) cause much smaller spikes in blood triglycerides after eating compared to other types of fats.
- Heart Health
Settings Order Article Reprints Open AccessArticle β Hydroxybutyrate, A Ketone Body, Potentiates The Antioxidant Defense Via Thioredoxin 1 Upregulation In Cardiomyocytes
Researchers found that beta-hydroxybutyrate (a ketone produced during fasting or ketogenic diets) helps protect heart cells from damage by boosting their natural antioxidant defenses.
- Heart Health
Severe Clinical Manifestation Of Mitochondrial 3 Hydroxy 3 Methylglutaryl CoA Synthase Deficiency Associated With Two Novel Mutations A Case Report
Researchers report a severe case of a rare genetic condition that prevents the body from properly breaking down fats for energy during illness or fasting.
- Heart Health
Sex Difference In Human Mevalonate Metabolism
This study found that women and men process mevalonate (a cholesterol precursor) differently, with women breaking it down faster than men.
- Heart Health
Short Chain Fatty Acids Outpace Ketone Oxidation In The Failing Heart
Researchers found that failing hearts can better use short-chain fatty acids (from gut bacteria) than ketones for energy when their normal fat-burning ability is impaired.
- Heart Health
ß Hydroxybutyrate Improves Mitochondrial Function After Transient Ischemia In The Mouse
Researchers found that beta-hydroxybutyrate (a ketone produced during fasting) helped protect brain cells and improve their energy production after a stroke in mice.
- Heart Health
Statin Therapy Is Not Warranted For A Person With High LDL Cholesterol On A Low Carbohydrate Diet
Researchers argue that people following low-carbohydrate diets may not need cholesterol-lowering statin medications, even if their LDL cholesterol levels are high.
- Heart Health
Statin Use Is Associated With A Decline In Muscle Function And Mass Over Time, Irrespective Of Statin Pharmacogenomic Score
A large study found that people taking statins experienced faster decline in muscle strength and mass over time compared to those not taking these cholesterol medications.
- Heart Health
Statins As Antithrombotic Drugs
Statins may protect against heart attacks and strokes not only by lowering cholesterol, but also by directly preventing dangerous blood clots from forming.
- Heart Health
Subchronic Toxicity Of Atorvastatin, A Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor, In Beagle Dogs
Researchers tested very high doses of atorvastatin (a cholesterol-lowering statin drug) in dogs to understand its safety profile before human use.
- Heart Health
Subendothelial Lipoprotein Retention As The Initiating Process In Atherosclerosis Update And Therapeutic Implications
Researchers explain how cholesterol-carrying particles get trapped in artery walls, triggering inflammation that leads to heart disease and potential new treatment approaches.
- Heart Health
Sugar And CV Dz Children
Children who consume high amounts of added sugar show increased risk factors for heart disease, even at levels below what most kids currently eat.
- Heart Health
Summary Of American Heart Association Diet And Lifestyle Recommendations Revision 2006
The American Heart Association's 2006 guidelines provide evidence-based diet and lifestyle recommendations that can substantially reduce cardiovascular disease risk for the general population.
- Heart Health
Targeting NO
This research review explores how natural compounds like polyphenols can boost nitric oxide production to improve blood vessel health and reduce cardiovascular disease risk.
- Heart Health
Tea Flavonoids And Cardiovascular Health 2013 The American Journal Of Cl
This research review explains how drinking tea may protect your heart by improving blood vessel function through natural compounds called flavonoids.
- Heart Health
THE ANDROGEN RECEPTOR PLAYS DIFFERENT ROLES IN MACROPHAGE INDUCED PROLIFERATION IN PROSTATE STROMAL CELLS BETWEEN TRANSITIONAL AND PERIPHERAL ZONES OF BENIGN PROSTATIC HYPERTROPHY
Researchers discovered that immune cells called macrophages promote prostate enlargement differently in various parts of the prostate, which could lead to better targeted treatments.
- Heart Health
THE BLOOD CHOLESTEROL FOLLOWING REPEATED ADMINISTR
A 1930 study found that repeated exposure to certain anesthetic chemicals caused blood cholesterol levels to rise significantly above normal in laboratory rabbits.
- Heart Health
The Cardiometabolic Consequences Of Replacing Saturated Fats With Carbohydrates Or Ω 6 Polyunsaturated Fats Do The Dietary Guidelines Have It Wrong
This research challenges decades of dietary advice by showing that replacing saturated fats with refined carbohydrates may have worsened America's diabetes and obesity epidemics.
- Heart Health
The Cholesterol Paradox In Long Livers From A Sardinia Longevity Hot Spot (Blue Zone)
A study of people in their 90s from Sardinia's "Blue Zone" found that those with higher LDL ("bad") cholesterol levels actually lived longer than those with lower levels.
- Heart Health
The Cholesterol Paradox In Long Livers From Sardinia
Researchers found that people in their 90s from Sardinia's "Blue Zone" lived longer when they had higher cholesterol levels, challenging conventional wisdom about cholesterol and heart health.
- Heart Health
The Effect Of Oral Glucose Tolerance Testing On Changes In Arterial Stiffness And Blood Pressure In Elderly Women With Hypertension And Relationships Between The Stage Of Diabetes And Physical Fitness Levels
This study found that elderly women with both high blood pressure and diabetes showed impaired blood vessel responses after consuming a glucose drink, suggesting compromised vascular health.
- Heart Health
The Effect Of α Tocopherol Supplementation On LDL Oxidation A Dose Response Study
Researchers tested different doses of vitamin E supplements to find the minimum amount needed to protect LDL cholesterol from becoming oxidized and potentially harmful to arteries.
- Heart Health
The Effects Of SGLT2 Inhibitors On Lipid Metabolism
SGLT2 inhibitors, diabetes medications that work through the kidneys, have beneficial effects beyond blood sugar control by improving how the body processes fats and burns fuel.
- Heart Health
The Influence Of Cholesterol On Membrane Protein
This research review examines how cholesterol levels in cell membranes affect the function of important proteins, which could impact heart health and disease.
- Heart Health
The Lipid Energy Model Reimagining Lipoprotein Function In The Context Of Carbohydrate Restricted Diets
Researchers propose a new model explaining why some lean people on low-carb diets develop very high cholesterol levels that may not indicate increased heart disease risk.
- Heart Health
The Microbial Gbu Gene Cluster Links Cardiovascular Disease Risk Associated With Red Meat Consumption To Microbiota L Carnitine Catabolism
Scientists discovered specific gut bacteria genes that help explain why eating red meat may increase heart disease risk through the breakdown of a compound called carnitine.
- Heart Health
The Pathology Of Atherosclerosis Plaque Development And Plaque Responses To Medical Treatment
Atherosclerosis (artery hardening) develops over 50 years starting in teens, but statin medications can significantly slow progression and reduce heart disease risk even in advanced cases.
- Heart Health
The Protective Effect Of 1,25(OH)2D3 On Myocardial Function Is Mediated Via Sirtuin 3 Regulated Fatty Acid Metabolism
Vitamin D protects heart function by regulating how heart cells process fats for energy through a specific protein pathway.
- Heart Health
The Real Offending Factor In Hypertension
Researchers are questioning whether blood flow, rather than blood pressure itself, may be the real culprit behind artery damage in hypertension.
- Heart Health
The Response To Retention Hypothesis Of Early Atherogenesis
Researchers propose that the buildup of cholesterol-carrying particles beneath artery walls, rather than artery damage, is the primary trigger that starts heart disease.
- Heart Health
The Search For The Perfect Heart Healthy Diet Jmcp
Research comparing low-carb Atkins diet to low-fat diets for heart health shows mixed results, with studies limited by poor patient compliance and small sample sizes.
- Heart Health
The Small Leucine Rich Repeat Proteoglycans In Tissue Repair And Atherosclerosis
Researchers studied how specific proteins called SLRPs affect the development of atherosclerosis (artery-clogging plaque) and tissue repair processes that impact heart disease.
- Heart Health
The Toxicology Of HMG—CoA Reductase Inhibitors Prediction Of Human Risk
Researchers studied the safety of statin cholesterol medications by testing them in animals first, successfully predicting that most side effects seen in animals wouldn't occur in humans.
- Heart Health
Thematic Review Series The Pathogenesis Of Atherosclerosis. An Interpretive History Of The Cholesterol Controversy Part I
This article reviews the historical controversy around whether high cholesterol causes heart disease, a debate that raged for decades before being settled.
- Heart Health
Thematic Review Series The Pathogenesis Of Atherosclerosis. An Interpretive History Of The Cholesterol Controversy Part II The Early Evidence Linking Hypercholesterolemia To Coronary Disease In Humans
This historical review examines how scientists established the connection between high cholesterol levels and heart disease in humans during the early decades of cholesterol research.
- Heart Health
Thematic Review Series The Pathogenesis Of Atherosclerosis. An Interpretive History Of The Cholesterol Controversy, Part III Mechanistically Defining The Role Of Hyperlipidemia
This historical review explains how the medical community slowly accepted that high cholesterol causes heart disease, despite strong evidence existing for decades.
Disclaimer: this library, including every summary, is for general informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before changing your diet, exercise, or health regimen, or if you have questions about a medical condition.