Metabolic
Library
1,810 peer-reviewed papers, each with a plain-language summary and the source document. The evidence behind the VALIA method, kept where you can read it.
Educational information only. Not medical advice, diagnosis or treatment. For anything about your own health, speak with a clinician. To become a patient, start at our contact page.
1,810 papers
· 13 topics
Search results
1,810 results · page 35 of 38
- Evolutionary Health and Aging
The Neanderthal Meal A New Perspective Using Faecal Biomarkers
Scientists analyzed 50,000-year-old Neanderthal waste to discover they ate both meat and plants, showing similar gut bacteria and cholesterol processing to modern humans.
- Nutrition and Health
THE NECESSITY OF CERTAIN LIPINS IN THE DIET DURING GROWTH
This 1913 study found that rats could grow normally for 2-4 months on purified diets without natural fats, but eventually needed real food sources to continue thriving.
- Brain and Nerve Health
The Neuropharmacology Of The Ketogenic Diet
The ketogenic diet may protect against seizures by changing how the brain uses energy, switching from glucose to ketones as fuel.
- Nutrition and Health
The Neurotoxic Effects Of Vitamin A And Retinoids
While vitamin A is essential for health, taking doses higher than nutritionally needed may cause harmful effects on the nervous system.
- Nutrition and Health
The New Ketone Alphabet Soup BHB, HCA, And HDAC
Scientists discovered that beta-hydroxybutyrate (a ketone produced during fasting or ketogenic diets) may protect the brain by reducing harmful oxidative stress and changing gene activity.
- Heart Health
The Pathology Of Atherosclerosis Plaque Development And Plaque Responses To Medical Treatment
Atherosclerosis (artery hardening) develops over 50 years starting in teens, but statin medications can significantly slow progression and reduce heart disease risk even in advanced cases.
- Nutrition and Health
The Place Of Meat In Dietary Policy An Exploration Of The Animal Plant Divide
This research paper argues that the current strong preference for plant-based diets over meat-eating is a cultural trend rather than purely science-based.
- Mental Health
The Plasma Levels Of 3 Hydroxybutyrate, Dityrosine, And Other Markers Of Oxidative Stress And Energy Metabolism In Major Depressive Disorder
Researchers found that people with major depression have elevated levels of ketones and oxidative stress markers in their blood compared to healthy individuals.
- Nutrition and Health
The Potential Health Benefits Of The Ketogenic Diet A Narrative Review
This research review examines how ketogenic diets (very low-carb, high-fat eating patterns) may benefit multiple aspects of health including diabetes management, weight loss, heart health, and cancer treatment.
- Nutrition and Health
The Potential Health Benefits Of The Ketogenic Diet A Narrative Review
This review examines evidence that ketogenic diets (very low-carb, high-fat eating) may benefit multiple aspects of health including diabetes control, weight loss, heart health, and cancer treatment.
- Liver and Kidney Health
The Potential Of Organoids In Urological Cancer Research
Scientists are developing lab-grown mini-organs called organoids to better understand and find personalized treatments for kidney, bladder, and prostate cancers.
- Liver and Kidney Health
The Potential Roles Of Very Low Calorie, Very Low Calorie Ketogenic Diets And Very Low Carbohydrate Diets On The Gut Microbiota Composition
Very low-calorie and ketogenic diets change the balance of bacteria in your gut, which may affect how your body processes nutrients and maintains health.
- Mental Health
The Prevalence Of Food Addiction As Assessed By The Yale Food Addiction Scale A Systematic Review
A comprehensive review found that about 1 in 5 people (19.9%) show signs of food addiction, with higher rates in women, adults over 35, and those who are overweight.
- Liver and Kidney Health
The Prevalence Of Non Alcoholic Fatty Liver Disease In Children And Adolescents A Systematic Review And Meta Analysis
This large research review found that fatty liver disease affects about 8% of children overall and 34% of children with obesity.
- Heart Health
The Protective Effect Of 1,25(OH)2D3 On Myocardial Function Is Mediated Via Sirtuin 3 Regulated Fatty Acid Metabolism
Vitamin D protects heart function by regulating how heart cells process fats for energy through a specific protein pathway.
- Liver and Kidney Health
The Quantitative Role Of The Kidneys In The In Viuo Metabolism Of Mevalonate
Research found that kidneys play a surprisingly major role in processing mevalonate, a key building block for cholesterol production in the body.
- Heart Health
The Real Offending Factor In Hypertension
Researchers are questioning whether blood flow, rather than blood pressure itself, may be the real culprit behind artery damage in hypertension.
- Gut Health
The Relationhip Between Number Of Stenotic Coronary Arteries And The Gut Microbiome In Coronary. Heart Disease Patients
Researchers found that people with more blocked heart arteries have different gut bacteria patterns, suggesting the microbiome may influence heart disease severity.
- Mental Health
The Relationship Between Linoleic Acid Intake And Psychological Disorders In Adults
A large study of Iranian adults found that people who ate the most linoleic acid (a common omega-6 fat found in vegetable oils) were 41% more likely to have depression.
- Dental Health
The Relationship Between Oral Health And Diabetes Mellitus
Research shows that gum disease (periodontitis) and diabetes have a two-way relationship where each condition can worsen the other.
- Heart Health
The Response To Retention Hypothesis Of Early Atherogenesis
Researchers propose that the buildup of cholesterol-carrying particles beneath artery walls, rather than artery damage, is the primary trigger that starts heart disease.
- Joint, Muscle Health and Exercise
The Role Of BHB In Mitigating Inflammatory Effects Of Uric Acid
Beta-hydroxybutyrate (a ketone produced during fasting) may help reduce inflammation and cellular damage caused by high uric acid levels.
- Joint, Muscle Health and Exercise
The Role Of BHB In Mitigating Inflammatory Effects Of Uric Acid(1)
Researchers found that beta-hydroxybutyrate (a compound your body makes during fasting) can reduce the inflammation and cellular damage caused by high uric acid levels.
- Hormone Health
The Role Of Eating Behavior Traits In Mediating 2018 The American Journal Of
Researchers found that genetic predisposition to obesity works partly through specific eating behaviors like loss of control around food and increased hunger sensitivity.
- Hormone Health
The Role Of Eating Behavior Traits In Mediating 2018 The American Journal Of(1)
Researchers found that genetic predisposition to obesity partly works through eating behaviors like loss of control around food and increased hunger sensitivity.
- Hormone Health
The Role Of Gallbladder Emptying In Gallstone Formation During Diet Induced Rapid Weight Loss
People on very low-fat rapid weight loss diets developed more gallstones than those eating moderate fat because their gallbladders didn't empty properly.
- Gut Health
The Role Of Gut Microbiota And Diet On Uremic Retention Solutes Production In The Context Of Chronic Kidney Disease
Researchers found that gut bacteria and diet choices significantly influence the production of harmful waste products that accumulate in chronic kidney disease patients.
- Evolutionary Health and Aging
The Role Of Meat In The Human Diet Evolutionary Aspects And Nutritional Value
This research review examines how humans evolved to include meat in their diet and explains meat's unique nutritional benefits that may be difficult to replace with plant-only foods.
- Liver and Kidney Health
The Role Of Palmitoleic Acid In Regulating Hepatic Gluconeogenesis Through SIRT3 In Obese Mice
Researchers found that palmitoleic acid (a fatty acid found in certain foods) helps reduce the liver's production of excess glucose in obese mice, potentially offering benefits for blood sugar control.
- Liver and Kidney Health
The Role Of Short Chain Fatty Acids In Mediating Very Low Calorie Ketogenic Diet Infant Gut Microbiota Relationships And Its Therapeutic Potential In Obesity
This research explores how very low-carb ketogenic diets during pregnancy and breastfeeding might protect infants from obesity by promoting healthy gut bacteria that produce beneficial fatty acids.
- Nutrition and Health
The Role Of The Anabolic Properties Of Plant Versus Animal Based Protein Sources In Supporting Muscle Mass Maintenance A Critical Review
This research review compares how well plant-based versus animal-based proteins help maintain muscle mass, finding that animal proteins are more effective but plant proteins can be improved through specific strategies.
- Gut Health
The Role Of The Gut Microbiota On The Beneficial Effects Of Ketogenic Diets
This review explores how ketogenic diets may provide their health benefits through changes in gut bacteria, rather than just through ketosis itself.
- Liver and Kidney Health
The Role Of Very Low Calorie Ketogenic Diet In Sympathetic Activation Through Cortisol Secretion In Male Obese Population
This study examined how a very low-calorie ketogenic diet affects stress hormones like cortisol in obese men, which is important for understanding metabolism and weight loss.
- Hormone Health
The Role Of Very Low Calorie Ketogenic Diet In Sympathetic Activation Through Cortisol Secretion In Male Obese Population
This study examined how a very low-calorie ketogenic diet affects stress hormones like cortisol in obese men.
- Environment and Health
The Roles And Values Of Wild Foods In Agricultural Systems
Wild plants and animals provide significant nutrition to communities worldwide, with agricultural societies using 90-100 different wild food species on average, yet these foods are often overlooked in official food security assessments.
- Nutrition and Health
The Safety Limits Of An Extended Fast Lessons From A Non Model Organism
Researchers studied penguins to understand the safe limits of extended fasting, identifying warning signs that indicate when prolonged fasting becomes dangerous.
- Heart Health
The Search For The Perfect Heart Healthy Diet Jmcp
Research comparing low-carb Atkins diet to low-fat diets for heart health shows mixed results, with studies limited by poor patient compliance and small sample sizes.
- Liver and Kidney Health
The Serum Metabolome Identifies Biomarkers Of Dietary Acid Load In 2 Studies Of Adults With Chronic Kidney Disease
Researchers identified 13 blood markers that can accurately measure dietary acid load (the balance between acid-producing foods like meat and alkaline foods like vegetables) in kidney disease patients.
- Gut Health
The Small Intestine Converts Dietary Fructose Into Glucose And Organic Acids
This study reveals that the small intestine, not the liver, processes most dietary fructose from sugar when consumed in normal amounts.
- Heart Health
The Small Leucine Rich Repeat Proteoglycans In Tissue Repair And Atherosclerosis
Researchers studied how specific proteins called SLRPs affect the development of atherosclerosis (artery-clogging plaque) and tissue repair processes that impact heart disease.
- Evolutionary Health and Aging
The Societal Role Of Meat—what The Science Says
This scientific review examines whether meat should be part of a healthy human diet by analyzing evidence on nutrition, health, environmental impact, and ethics.
- Joint, Muscle Health and Exercise
The Source Of Glycolytic Intermediates In Mammalia
Researchers discovered that while most of the body's cells get their energy from stored glycogen, specialized tissues like red muscle preferentially burn circulating blood sugar.
- Liver and Kidney Health
The State Of Diabetes Treatment Coverage In 55 Low Income And Middle Income Countries A Cross Sectional Study Of Nationally Representative, Individual Level Data In 680 102 Adults
A large study found that most people with diabetes in lower-income countries worldwide are not receiving the medications and care they need to manage their condition.
- Environment and Health
The Sugar Industry S Efforts To Manipulate Research On Fluoride Effectiveness And Toxicity
This research reveals how the sugar industry funded scientists and organizations starting in the 1930s to promote fluoride as a tooth decay solution while protecting sugar's reputation.
- Brain and Nerve Health
The Therapeutic Potential Of Ketone Bodies In Parkinson’s Disease
This research explores how ketone bodies (natural compounds made during fasting or low-carb diets) might help protect brain cells and treat Parkinson's disease.
- Nutrition and Health
The Thiamine Status Of Adult Humans Depends On Carbohydrate Intake
Higher carbohydrate intake increases your body's need for thiamine (vitamin B1), potentially leading to deficiency even when total calories stay the same.
- Heart Health
The Toxicology Of HMG—CoA Reductase Inhibitors Prediction Of Human Risk
Researchers studied the safety of statin cholesterol medications by testing them in animals first, successfully predicting that most side effects seen in animals wouldn't occur in humans.
- Gut Health
The Way To A Mans Heart Is Through His Gut Microbiota Dietary Pro And Prebiotics For The Management Of Cardiovascular Risk
Research shows that gut bacteria may significantly influence heart disease risk, and eating more plant foods, probiotics, and prebiotics could protect your heart health.
Disclaimer: this library, including every summary, is for general informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before changing your diet, exercise, or health regimen, or if you have questions about a medical condition.