Metabolic
Library
1,810 peer-reviewed papers, each with a plain-language summary and the source document. The evidence behind the VALIA method, kept where you can read it.
Educational information only. Not medical advice, diagnosis or treatment. For anything about your own health, speak with a clinician. To become a patient, start at our contact page.
1,810 papers
· 13 topics
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1,810 results · page 36 of 38
- Nutrition and Health
The Whole Food Beef Matrix Is More Than The Sum Of Its Parts
This research argues that beef's health effects should be evaluated as a whole food rather than judging it solely by individual nutrients like saturated fat.
- Heart Health
Thematic Review Series The Pathogenesis Of Atherosclerosis. An Interpretive History Of The Cholesterol Controversy Part I
This article reviews the historical controversy around whether high cholesterol causes heart disease, a debate that raged for decades before being settled.
- Heart Health
Thematic Review Series The Pathogenesis Of Atherosclerosis. An Interpretive History Of The Cholesterol Controversy Part II The Early Evidence Linking Hypercholesterolemia To Coronary Disease In Humans
This historical review examines how scientists established the connection between high cholesterol levels and heart disease in humans during the early decades of cholesterol research.
- Heart Health
Thematic Review Series The Pathogenesis Of Atherosclerosis. An Interpretive History Of The Cholesterol Controversy, Part III Mechanistically Defining The Role Of Hyperlipidemia
This historical review explains how the medical community slowly accepted that high cholesterol causes heart disease, despite strong evidence existing for decades.
- Heart Health
Thematic Review Series The Pathogenesis Of Atherosclerosis. An Interpretive History Of The Cholesterol Controversy, Part IV The 1984 Coronary Primary Prevention Trial Ends It—almost
The landmark 1984 Coronary Primary Prevention Trial proved that lowering cholesterol with medication reduces heart attacks by 19%, finally convincing doctors to treat high cholesterol.
- Heart Health
Thematic Review Series The Pathogenesis Of Atherosclerosis. An Interpretive History Of The Cholesterol Controversy, Part V The Discovery Of The Statins And The End Of The Controversy
This historical review describes how the discovery of statin drugs in the 1980s finally proved that lowering cholesterol with medication dramatically reduces heart disease risk.
- Nutrition and Health
Therapeutic Carb Restriction
This study found that reducing carbohydrates in the diet significantly improved weight loss and the body's ability to burn fat for energy in clinic patients.
- Brain and Nerve Health
Therapeutic Potential Of Exogenous Ketone Supplement Induced Ketosis In The Treatment Of Psychiatric Disorders Review Of Current Literature
Researchers reviewed evidence that ketone supplements, which put the body into a metabolic state called ketosis, might help treat psychiatric conditions like anxiety, depression, and ADHD.
- Hormone Health
Thermodynamics Of Weight Loss Diets
This research challenges the "a calorie is a calorie" belief by showing that low-carbohydrate diets may cause more weight loss than other diets with the same number of calories.
- Environment and Health
Thermogenesis In Mice And Sunlight
Researchers discovered that fat cells can sense blue light and use it to help burn fat for warmth, which may explain why sunlight exposure affects metabolism.
- Heart Health
Thin Walled Microvessels In Human Coronary Atherosclerotic Plaques Show Incomplete Endothelial Junctions Relevance Of Compromised Structural Integrity For Intraplaque Microvascular Leakage
Researchers found that tiny blood vessels within heart artery plaques have structural weaknesses that allow dangerous leaking, potentially leading to plaque rupture and heart attacks.
- Hormone Health
Thyroid Function In Obese Children With Non Alcoholic Fatty Liver Disease
This study examined how thyroid hormone levels differ in obese teenagers with fatty liver disease compared to those without liver problems.
- Hormone Health
Thyroid Function In Obese Children With Non Alcoholic Fatty Liver Disease(1)
This study found that obese children with fatty liver disease had different thyroid hormone patterns compared to obese children without liver problems, suggesting these conditions may be connected.
- Hormone Health
Thyroid Hormone Levels In Obese Children And Adolescents With Non Alcoholic Fatty Liver Disease
This study examined how thyroid hormone levels relate to fatty liver disease in obese children and teenagers.
- Hormone Health
Thyroid Hormone Levels In Obese Children And Adolescents With Non Alcoholic Fatty Liver Disease(1)
This study examined how thyroid hormone levels relate to fatty liver disease in obese children and teenagers.
- Brain and Nerve Health
Time Restricted Ketogenic Diet In Huntington S Disease A Case Study
A 41-year-old man with Huntington's disease showed significant improvements in movement, daily functioning, and behavioral symptoms after following a time-restricted ketogenic diet for nearly a year.
- Nutrition and Health
Time Restriction Of Food Intake During The Circadi
This study found that when female rats ate during their natural active hours (nighttime), they maintained better reproductive health than when eating during inactive hours (daytime).
- Hormone Health
Timeline Of Changes In Appetite During Weight Loss With A Ketogenic Diet
A ketogenic very-low-calorie diet temporarily increases hunger for the first 3 weeks of weight loss, but appetite suppression returns while the body stays in ketosis.
- Liver and Kidney Health
Tolerance And Safety Evaluation Of N, N Dimethylglycine, A Naturally Occurring Organic Compound, As A Feed Additive In Broiler Diets
Researchers found that N,N-dimethylglycine (DMG), a natural compound involved in metabolism, improved feed efficiency in chickens without causing toxicity or harmful accumulation in tissues.
- Environment and Health
Total Zinc Absorption In Young Women, But Not Fractional Zinc Absorption, Differs Between Vegetarian And Meat Based Diets With Equal Phytic Acid Content
Vegetarian diets led to lower total zinc absorption than meat-based diets in young women, even when both diets contained equal amounts of phytic acid (a compound that blocks zinc absorption).
- Hormone Health
TOWARD, A Metabolic Health Intervention, Demonstrates Robust 1 Year Weight Loss And Cost Savings Through Deprescription
A telemedicine program using low-carb diets and lifestyle coaching helped employees lose 15.5% of their body weight over one year while reducing their need for medications and saving money.
- Nutrition and Health
Toxic Constituents Of Plant Foodstuffs
Many plant foods naturally contain toxic compounds that can interfere with digestion and nutrient absorption, but proper cooking and processing can eliminate these harmful substances.
- Evolutionary Health and Aging
Traditional Dietary Patterns And Risk Of Mortality In A Longitudinal Cohort Of The Salus In Apulia Study
A 32-year study of Southern Italian adults found that eating certain traditional foods like eggs and fatty meats was linked to lower death rates.
- Evolutionary Health and Aging
Translating PUFA Omega 6 3 Ratios From Wild To Captive Hibernators (Urocitellus Parryii) Enhances Sex Dependent Mass Gain Without Increasing Physiological Stress Indicators
Researchers found that feeding hibernating ground squirrels a diet with balanced omega-6 to omega-3 fatty acid ratios (similar to their wild diet) helped females gain more weight before hibernation without increasing stress.
- Mental Health
Treating Binge Eating And Food Addiction Symptoms With Low Carbohydrate Ketogenic Diets A Case Series
A ketogenic diet helped three patients with obesity significantly reduce binge eating episodes and food cravings while losing 10-24% of their body weight.
- Hormone Health
Treating Diabetes Utilizing A Low Carbohydrate Ketogenic Diet And Intermittent Fasting Without Significant Weight Loss A Case Report
Three diabetes patients significantly improved their blood sugar control using a low-carb ketogenic diet and intermittent fasting, even without losing substantial weight.
- Nutrition and Health
Treatment Of Dravet Syndrome
This medical review outlines treatment approaches for Dravet syndrome, a severe childhood epilepsy condition that includes the ketogenic diet as a second-line therapy option.
- Heart Health
Treatments For Skeletal Muscle Abnormalities In Heart Failure Sodium Glucose Transporter 2 And Ketone Bodies
Researchers are investigating whether SGLT2 inhibitor medications could help heart failure patients by improving muscle energy problems that cause exercise intolerance.
- Heart Health
Trends In Risk Profiles Among Adults With Cardiovascular Disease USA
A 20-year study found that Americans with heart disease showed mixed progress on health factors, with cholesterol control improving significantly while weight management and blood sugar control worsened.
- Heart Health
Trial Level Surrogacy Of Non High Density And Low Density Lipoprotein Cholesterol Reduction On The Clinical Efficacy Of Statins
This study found that cholesterol level improvements from statin medications don't reliably predict how much they actually reduce heart attacks and deaths.
- Nutrition and Health
Tricaprylin Alone Increases Plasma Ketone Response More Than Coconut Oil Or Other Medium Chain Triglycerides An Acute Crossover Study In Healthy Adults
Pure C8 oil (caprylic acid) raises blood ketones much more effectively than coconut oil or other medium-chain triglyceride supplements in healthy adults.
- Heart Health
Tufts MetHealth Article
American heart health has gotten significantly worse over the past two decades, with rising obesity and diabetes being the main culprits behind this alarming trend.
- Heart Health
Tunica Media Dysfunction And Primary Hypertension
This research proposes that primary high blood pressure may be caused by damage to the middle layer of artery walls, which affects how blood vessels contract and relax.
- Heart Health
UK Food Standards Agency Workshop Report Carbohydrate And Cardiovascular Risk
UK researchers reviewed studies examining how different types of carbohydrates affect heart disease risk to guide future nutrition recommendations.
- Nutrition and Health
Ultra Processed Food Consumption And Chronic Non Communicable Diseases Related Dietary Nutrient Profile In The UK (2008–2014)
This UK study found that people eating more ultra-processed foods consumed significantly more sugar and sodium while getting less protein and fiber, increasing their risk of chronic diseases.
- Mental Health
Ultra Processed Food Consumption And Mental Health A Systematic Review And Meta Analysis Of Observational Studies
A large study found that people who eat more ultra-processed foods have significantly higher rates of depression and anxiety symptoms.
- Mental Health
Ultra Processed Food Exposure And Adverse Health Outcomes
A large research review found that eating more ultra-processed foods increases the risk of heart disease, diabetes, anxiety, depression, and early death.
- Nutrition and Health
Ultra Processed Foods What They Are And How To Identify Them
Ultra-processed foods are industrial products made with ingredients you wouldn't find in a home kitchen, and they now make up over half of what people eat in wealthy countries.
- Dental Health
Ultra Processed Foods And Early Childhood Caries In 0–3‐year‐olds Enrolled At Primary Healthcare Centers In Southern Brazil
Children who eat ultra-processed foods four or more times daily have over twice the risk of developing tooth decay compared to those eating them less frequently.
- Gut Health
Ultra Processed Foods As A Possible Culprit For The Rising Prevalence Of Inflammatory Bowel Diseases
This research explores how ultra-processed foods like packaged snacks and fast food may contribute to the rising rates of inflammatory bowel diseases.
- Mental Health
Ultraprocessed Food And Depression
A large study of middle-aged women found that eating more ultraprocessed foods (like packaged snacks, ready meals, and sugary drinks) was linked to higher rates of depression.
- Mental Health
UltraProcessed Foods And Health
Research suggests ultra-processed foods may harm mental health and contribute to antisocial behavior through biological pathways including gut bacteria changes.
- Gut Health
Understanding The Gut Microbiota By Considering Human Evolution A Story Of Fire, Cereals, Cooking, Molecular Ingenuity, And Functional Cooperation
This research explores how our gut bacteria evolved alongside humans as we learned to use fire, cook food, and farm grains, shaping the microbes that now help digest our modern diet.
- Gut Health
Understanding The Physics Of Functional Fibers In The G 2017 Journal Of The
This research clarifies how different types of fiber work in your digestive system, showing that viscous (gel-forming) fibers like psyllium are most effective for cholesterol and blood sugar control.
- Evolutionary Health and Aging
Unifying Model For Timing Of Walking Onset In Humans And Other Mammals
Scientists discovered that the timing of when babies learn to walk is primarily determined by brain size and development that begins before birth, not after.
- Nutrition and Health
Unintended Consequences Nutritional Impact And Potential Pitfalls Of Switching From Animal To Plant Based Foods
While traditional plant-based foods like legumes and vegetables offer health benefits, newer processed plant-based meat alternatives may actually contain more saturated fat, sodium, and sugar while lacking important nutrients.
- Nutrition and Health
Unprocessed And Processed Meat
A major research review found that current evidence doesn't strongly support reducing red meat or processed meat consumption, contrary to many existing dietary guidelines.
- Evolutionary Health and Aging
Unveiling The Hidden Therapeutic Potential Of Carnosine, A Molecule With A Multimodal Mechanism Of Action A Position Paper
Carnosine, a natural compound found in muscle tissue, shows promise as a therapeutic supplement with multiple health benefits, but more standardized research is needed.
Disclaimer: this library, including every summary, is for general informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before changing your diet, exercise, or health regimen, or if you have questions about a medical condition.