Metabolic
Library
1,810 peer-reviewed papers, each with a plain-language summary and the source document. The evidence behind the VALIA method, kept where you can read it.
Educational information only. Not medical advice, diagnosis or treatment. For anything about your own health, speak with a clinician. To become a patient, start at our contact page.
1,810 papers
· 13 topics
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1,810 results · page 21 of 38
- Heart Health
Ketogenic Diet Suppressed T Regulatory Cells And Promoted Cardiac Fibrosis Via Reducing Mitochondria Associated Membranes And Inhibiting Mitochondrial Function
This study found that ketogenic diets may harm heart function in diabetic mice by reducing protective immune cells and increasing heart scarring, despite improving blood sugar control.
- Brain and Nerve Health
Ketogenic Diet Therapy For The Treatment Of Post Encephalitic And Autoimmune Associated Epilepsies
A ketogenic-style diet called the modified Atkins diet helped reduce seizures in 70% of patients with epilepsy caused by brain inflammation or autoimmune conditions.
- Nutrition and Health
Ketogenic Diet Treatment Of Defects In The Mitochondrial Malate Aspartate Shuttle And Pyruvate Carrier
A small study found that people with relapsing-remitting multiple sclerosis experienced less fatigue and depression after following a ketogenic diet for six months.
- Brain and Nerve Health
Ketogenic Diet(1)
The ketogenic diet, originally developed in 1921 to mimic fasting, can effectively control seizures in epilepsy patients who don't respond well to medications.
- Liver and Kidney Health
Ketogenic Dietary Interventions In PCKD
A study found that ketogenic diets and time-restricted eating may help people with polycystic kidney disease manage their symptoms and overall health.
- Liver and Kidney Health
Ketogenic Dietary Interventions In PCKD OCRed
A study found that ketogenic diets and time-restricted eating may be safe and potentially beneficial for people with polycystic kidney disease, with most participants reporting improved health.
- Nutrition and Health
Ketogenic Diets Boon Or Bane
Ketogenic diets drastically reduce carbohydrates to force the body to burn fat for energy, creating a metabolic state called ketosis.
- Joint, Muscle Health and Exercise
Ketogenic Diets And Physical Performance
Research shows that ketogenic (very low-carb) diets can support physical performance when properly implemented with adequate time for adaptation and proper electrolyte balance.
- Liver and Kidney Health
Ketogenic For Renal Dz
Ketogenic metabolic therapy, which restricts carbohydrates to shift the body into using fat for fuel, may safely improve kidney function in people with chronic kidney disease.
- Mental Health
KetogenicDiet Mental Health
Researchers found that ketogenic diets may help treat mental health conditions like depression and bipolar disorder by addressing underlying metabolic problems in the brain.
- Nutrition and Health
Ketolysis Is A Metabolic Driver Of CD8+ T Cell Effector Function Through Histone Acetylation
Researchers discovered that ketones (molecules produced during fasting or low-carb diets) fuel immune cells called CD8+ T cells, making them more effective at fighting infections and diseases.
- Brain and Nerve Health
Ketone Bodies In Epilepsy
Ketogenic diets can reduce seizures by 75% in children with epilepsy by producing ketone bodies that the brain can use as an alternative fuel source.
- Brain and Nerve Health
Ketone Bodies In Neurodegenerative Disease
Ketone bodies, produced during fasting or ketogenic diets, can provide alternative brain fuel that may help protect against neurodegenerative diseases like Alzheimer's and Parkinson's.
- Heart Health
Ketone Body 3 Hydroxybutyrate Ameliorates Atherosclerosis Via Receptor Gpr109a Mediated Calcium Influx
Researchers found that 3-hydroxybutyrate, a ketone body produced during fasting or ketogenic diets, significantly reduced artery-clogging plaque in mice by reducing harmful inflammation.
- Liver and Kidney Health
Ketone Body 3 Hydroxybutyrate Enhances Adipocyte Function
Researchers found that 3-hydroxybutyrate, a ketone body produced during fasting, helps fat cells function better by improving their ability to handle stress and respond to insulin.
- Heart Health
Ketone Body Improves Neurological Outcomes After Cardiac Arrest By Inhibiting Mitochondrial Fission In Rats
Researchers found that ketones (β-hydroxybutyrate) protected brain function and improved survival in rats after cardiac arrest by preserving the health of cellular powerhouses called mitochondria.
- Gut Health
Ketone Body β Hydroxybutyrate Ameliorates Colitis By Promoting M2 Macrophage Polarization Through The STAT6 Dependent Signaling Pathway
Ketones (specifically beta-hydroxybutyrate) may help reduce intestinal inflammation by encouraging immune cells to switch into a healing mode rather than an inflammatory one.
- Nutrition and Health
Ketone Body β Hydroxybutyrate Is An Autophagy Dependent Vasodilator
Research shows that beta-hydroxybutyrate, a ketone body produced during fasting or low-carb diets, helps blood vessels relax and widen through a cellular recycling process called autophagy.
- Heart Health
Ketone Body β Hydroxybutyrate Prevents Myocardial Oxidative Stress In Septic Cardiomyopathy
Researchers found that beta-hydroxybutyrate, a ketone body produced during fasting or ketogenic diets, may protect the heart from damage during severe infections called sepsis.
- Nutrition and Health
Ketone Ester Effects On Metabolism And Transcription
Researchers developed a ketone ester supplement that may provide the metabolic benefits of ketosis without the potential cardiovascular risks of high-fat ketogenic diets.
- Evolutionary Health and Aging
Ketones Potential To Achieve Brain Energy Rescue And Sustain Cognitive Health During Ageing
Research suggests that ketones (molecules produced during fasting or low-carb diets) may help protect brain function and memory as we age by providing an alternative fuel source when the brain struggles to use glucose effectively.
- Heart Health
Ketones Flux Through BDH1 Supports Metaboic Remodeling Of Skeletal And Cardiac Muscles
Researchers found that a specific enzyme helps heart and skeletal muscles use ketones more efficiently during intermittent time-restricted eating, improving fat burning and exercise performance.
- Joint, Muscle Health and Exercise
Ketones For Post Exercise Recovery Potential Applications And Mechanisms
This review examines how ketone supplements may help muscles recover faster after exercise, even though their effects on immediate exercise performance are mixed.
- Liver and Kidney Health
KETONES INHIBIT MITOCHONDRIAL PRODUCTION OF REACTIVE OXYGEN SPECIES PRODUCTION FOLLOWING GLUTAMATE EXCITOTOXICITY BY INCREASING NADH OXIDATION
Ketones produced during fasting or ketogenic diets protect brain cells from damage by reducing harmful free radicals and improving cellular energy production.
- Brain and Nerve Health
Ketones Prevent Oxidative Impairment Of Hippocampal Synaptic Integrity Through K ATP Channels
Researchers found that ketones protect brain cells from damage by activating specific channels that help preserve brain function during oxidative stress.
- Nutrition and Health
Ketones Regulate Endothelial Homeostasis
Researchers found that ketones (molecules produced during fasting or low-carb diets) help maintain healthy blood vessels in the heart by promoting the growth of new vessel cells.
- Heart Health
Ketones Step To The Plate A Game Changer For Metabolic Remodeling In Heart Failure
New research shows that failing hearts switch from using fats and sugars to using ketones (molecules made during fasting) as their primary fuel source.
- Nutrition and Health
Ketonuria After Fasting May Be Related To The Metabolic Superiority
People who produce ketones in their urine after fasting for 8+ hours showed better metabolic health markers and lower rates of obesity and metabolic syndrome.
- Nutrition and Health
Ketonuria After Fasting May Be Related To The Metabolic Superiority
A study of over 16,000 people found that those who produce ketones (fat-burning compounds) after an 8-hour fast had better metabolic health markers and lower rates of obesity.
- Nutrition and Health
Ketonuria And Seizure Control In The Medium Chain Triglyceride And Classic Ketogenic Diets
Two types of ketogenic diets showed similar effectiveness in reducing seizures in children with epilepsy, even though one produced lower ketone levels.
- Liver and Kidney Health
Ketosis
This medical case study examines a diabetic patient who developed ketosis, a condition where the body burns fat for energy instead of glucose, leading to dangerous acid buildup in the blood.
- Nutrition and Health
Ketosis After Intake Of Coconut Oil And Caprylic Acid—With And Without Glucose A Cross Over Study In Healthy Older Adults
This study found that coconut oil and caprylic acid can trigger ketosis (a fat-burning metabolic state) in older adults, even when consumed with glucose.
- Liver and Kidney Health
Ketosis Ameliorates Renal Cyst Growth In PCKD
Researchers found that ketosis - whether from fasting, ketogenic diets, or ketone supplements - can slow or reverse the growth of kidney cysts in polycystic kidney disease.
- Heart Health
Ketosis Prevents Abdominal Aortic Aneurysm Progression And Rupture In Male Rats
Researchers identified seven blood markers that may actually cause peripheral artery disease (blocked leg arteries), which could help doctors better predict and prevent this serious condition.
- Hormone Health
Ketosis Suppression And Ageing (KetoSAge) Part 2 The Effect Of Suppressing Ketosis On Biomarkers Associated With Ageing, HOMA IR, Leptin, Osteocalcin, And GLP 1, In Healthy Females
Researchers found that temporarily stopping a ketogenic diet in healthy women led to worse insulin sensitivity and other markers linked to aging and metabolic health.
- Liver and Kidney Health
Kidney Stones A Fetal Origins Hypothesis
Researchers propose that kidney stones may be linked to low birth weight and early life stress, which could also explain why kidney stone patients often develop diabetes, high blood pressure, and bone problems.
- Joint, Muscle Health and Exercise
L Arginine Supplementation Improves Exercise Ca 2010 The American Journal Of
L-arginine supplements improved exercise capacity and quality of life in heart transplant patients by enhancing blood vessel function.
- Joint, Muscle Health and Exercise
L Arginine Supplementation Improves Exercise Ca 2010 The American Journal Of(1)
L-arginine supplements improved exercise capacity and quality of life in heart transplant patients by enhancing blood vessel function.
- Liver and Kidney Health
L Carnitine In NAFLD
L-carnitine, a nutrient that helps transport fats for energy production, may reduce liver fat and improve liver function in people with fatty liver disease.
- Gut Health
L Carnitine In Omnivorous Diets Induces An Atherogenic Gut Microbial Pathway In Humans
This study found that people who eat meat produce much more of a harmful compound called TMAO from L-carnitine supplements compared to vegetarians, potentially increasing heart disease risk.
- Environment and Health
Landscape Composition Overrides Field Level Manageme 2019 Agriculture Ecosy
A three-year study in Ethiopia found that the surrounding landscape affects crop pest levels more than individual farming practices, highlighting how environmental factors influence food production.
- Heart Health
Large Scale Metabolomic Profiling Identifies Novel Biomarkers For Incident Coronary Heart Disease
Researchers identified four blood molecules that can help predict heart disease risk, potentially improving early detection beyond traditional risk factors.
- Nutrition and Health
Large State Variation In Sugar Sweetened Beverage
Sugar-sweetened beverage consumption varies dramatically across US states, with some states consuming more than twice as much as others.
- Evolutionary Health and Aging
Late Bronze Age Cultural Origins Of Dairy Pastoralism In Mongolia
Researchers discovered that people in Mongolia began consuming dairy products about 3,000 years ago, developing fermented milk beverages to avoid lactose intolerance symptoms.
- Evolutionary Health and Aging
Late Pleistocene Climate Induced Changes In Paleo Vegetat 2021 Quaternary Sc
Scientists studied how climate changes over 40,000 years affected forest types in Borneo and may have influenced early human population separation and genetic diversity.
- Evolutionary Health and Aging
Late Pleistocene South American Megafaunal Extinctions Associated With Rise Of Fishtail Points And Human Population
Researchers found evidence that early humans with advanced hunting tools likely caused the extinction of large Ice Age animals in South America around 13,000 years ago.
- Hormone Health
LCD Diet As Compared To Low Fat Diet For Obesity
A study of severely obese people found that those following a low-carbohydrate diet lost more weight and improved their blood sugar control better than those on a low-fat diet.
- Hormone Health
LCD Weight Loss Effects On Endothelial Funciton In CV Risk In Obesity
A study found that very low-carb diets are as safe for heart health as high-carb diets when used for weight loss in obese adults.
Disclaimer: this library, including every summary, is for general informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before changing your diet, exercise, or health regimen, or if you have questions about a medical condition.